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Opening Line: Oregon State -2.5

Schuster: Utah +3.5

The hook sold me here. Utah should be getting healthier and the return of Cam Rising cannot be understated. I’m very interested to see how Oregon State bounces back from an incredibly emotional game against Wazzu. I simply do not envy the Beavs’ schedule.

Scalici: Utah +3.5

It’s completely unfair to have to play one of the nastiest, meanest, most physical teams in college football one week after losing a gut-wrenching close call with Washington State. But life ain’t fair.

D’Andrea: Utah +3.5

I like the Beavers, and thus give them my blessing by picking against them.

Martinelli: Utah +3.5

I want to pick Oregon State at home, but that doesn’t feel like the logical choice. The Beavers are coming off a tough loss and face a Utah defense that’s ranked sixth in points allowed and 10th in total yards allowed. Whether or not Cam Rising is healthy, Utah wins this.

Nettuno: Utah +3.5

It seems like Cam Rising won’t play in this one, but it probably doesn’t matter. Utah looks like an elite team defensive, and DJ Uiagalelei had his share of struggles against a Washington State defense that isn’t nearly as fearsome.

Grimes: Utah +3.5

This feels like a defensive battle (or offensive struggle) that finishes within a field goal either way.

Darney: Utah +3.5

Utah is reaching “prove that I shouldn’t take you” territory at this point.

Northam: Oregon State -3.5

The Beavs bounce back at home. I don’t totally believe in Utah yet, and I’m not sure its offense can keep up with Oregon State’s, which is scoring 39.5 points per game, good enough for 20th in the nation.

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Opening Line: USC -14.5

Schuster: Colorado +21.5

The question isn’t about whether or not USC’s offense can grab a 22-point lead, but rather if the Trojans’ defense can hold it. I’m not convinced they can. This will surely backfire.

Scalici: Colorado +21.5

USC wins this game but there’s no way they shut down the Colorado offense the way Oregon did.

D’Andrea: USC -21.5

The pain is coming.

Martinelli: Colorado +21.5

A 21.5-point spread?? Against this USC defense?! Colorado will cover because the Trojans’ defense doesn’t seem to have made many improvements over the last year, and it’s decidedly not Oregon’s. This matchup is perfect for a high-scoring thriller, but USC still comes out on top.

Nettuno: Colorado +21.5

USC just isn’t good enough defensively to replicate what Oregon did to the Buffs. If Arizona State can put up 28 points on the Trojans, Colorado can at least top that. USC will win, but not by nearly this wide a margin.

Grimes: USC -21.5

The problem with Colorado is they can’t run the ball, which gives the other offense a lot of cracks at their defense. And when Bo Nix, or in this case, Caleb Williams, is the quarterback on the other side, that doesn’t leave me a lot of hope for a cover.

Darney: USC -21.5

It’s going to be difficult without Travis Hunter again, and I don’t know that Colorado can run the ball well enough to keep this within three touchdowns. Don’t feel great about this, though. I think USC wins easily but it could be 17.

Northam: Colorado +21.5

USC only beat Arizona State by 14 points, and I have a hard time seeing the Buffs getting absolutely blown out in back-to-back weeks. Back home in Boulder, they keep this score a little bit closer.

Kim Klement Neitzel-USA TODAY Sports

Opening Line: Kentucky -3

Schuster: Florida +1

Are the Wildcats legit or were they just playing Vandy last week?

Scalici: Florida +1.

I need to see more from Kentucky before I’m ready to believe. Florida took their lumps and appears to be getting better every week.

D’Andrea: Florida +1

The Wildcats were somehow unimpressive while covering the spread at Vanderbilt. Their first real test is gonna be a problem.

Martinelli: Florida +1

The Gators look fine, but I don’t trust this Kentucky team enough to pick it with a one-point spread.

Nettuno: Florida +1

I’ll never feel less confident in a pick than taking the Gators to win in Lexington, but I’m very bullish on what may be an elite Gators defense. Despite facing an easy slate through four weeks, the Wildcats have some issues offensively that Florida could take advantage of.

Grimes: Florida +1

Kentucky is going to pay for its turnovers sooner or later.

Darney: Kentucky -1

Wildcats at home, why not.

Northam: Florida +1

Kentucky ain’t played nobody yet and the Gators are about to expose them.

(Photo by Tim Warner/Getty Images)

Opening Line: Texas -19.5

Schuster: Kansas +16.5

The fact that this line opened with Texas as nearly a three touchdown favorite and has continued to drop speaks volumes. Do not be surprised if Kansas wins this game outright, but do yourself a favor and just grab the points to be safe.

Scalici: Kansas +16.5

Texas is a tremendously talented and well-coached team but I’m not sure they’re built for the kind of shoot-out Kansas is going to try to put them in.

D’Andrea: Kansas +16.5

The Longhorns are great, but the Jayhawks have kept this close in five of their last six games, which includes a stretch when they were utter dog [expletive]. Hilarious things happen when these teams meet.

Martinelli: Kansas +16.5

While it feels very possible that the Jayhawks could pull off an upset here, I think Texas still walks away with the W. However, this Kansas team — with a top-25 offense that’s averaging 463 yards per game — is being underestimated. Texas wins but not by 17 points.

Nettuno: Kansas +16.5

I doubt the Jayhawks catch Texas napping in Austin this time, but this is a legitimately good Kansas team that will give them troubles. KU has a top 25 defense right now, but Power Five contests against Illinois and BYU haven’t been the toughest tests. I’m not sure it can withstand Quinn Ewers, Xavier Worthy, AD Mitchell and Co.

Grimes: Kansas +16.5

With the exception of last year’s blowout, these games are typically close. And Kansas is playing good ball right now.

Darney: Texas -16.5

Jalon Daniels scares me and this line is huge, but the way Texas is playing and it being in Austin…I’m going to stick with the Longhorns. I’m already full of regret.

Northam: Kansas +16.5

If Texas really wants us to believe that it’s *back*, then the Longhorns will pummel the Jayhawks by three possessions. But my gut tells me that this is too many points, especially against a team with Jalon Daniels on the other side.

(Photo by Julio Aguilar/Getty Images)

Opening Line: LSU -4.5

Schuster: LSU -2.5

LSU should be a lot more focused after a major scare last week, but more than that, if Lane Kiffin is going to keep coaching games not to lose I’m going to continue picking against him. His play-calling against Alabama was atrocious.

Scalici: LSU -2.5

Bama Hangover is real. This is a deeply flawed LSU team but Ole Miss may need some time to recover, both physically and emotionally, from that deflating performance last week.

D’Andrea: Ole Miss +2.5

Noted southerner Brian Kelly will be too distracted by the sights and smells of the Grove to coach effectively.

Martinelli: LSU -2.5

This game, these teams, these coaches — this matchup has so much potential to be absolute (ugly or beautiful) chaos, and I’m so here for it. Your guess is as good as mine. But, begrudgingly, LSU to cover I guess.

Nettuno: LSU -2.5

The Tigers clearly have some defensive questions, but this spread just feels too small, even on the road. LSU has one of the most explosive offenses in the country, and I’m not sure an Ole Miss team led by an improved Jaxson Dart can keep up.

Grimes: LSU -2.5

My initial thought was LSU by a field goal, so this is perfect.

Darney: Ole Miss +2.5

Wrote a whole section on why I thought LSU would win, then deleted it because I hated it. This feels like it will be a more high-scoring affair than last week, but back and forth.

Northam: LSU -2.5

I lost all faith in Ole Miss being a darkhorse contender for the SEC West last week, and I don’t think LSU will start slow again like it did against Arkansas.

Matt Cashore-USA TODAY Sports

Opening Line: Notre Dame -6.5

Schuster: Notre Dame -5.5

I love this Duke team a lot and would probably pick them as a home dog in most other circumstances, but I still believe Notre Dame is a playoff-caliber team and they need a huge bounce-back win this week to prove it. Irish by a touchdown.

Scalici: Duke +5.5

Notre Dame has proven they’re legit but this game is coming at a terrible time for the Irish, fresh off a heartbreaking loss that took a physical toll.

D’Andrea: Duke +5.5

I want to believe. Also there’s a chance that putting 10 players on the field twice with the game on the line against Ohio State broke Marcus Freeman, much like the double-doink did to Matt Nagy.

Martinelli: Notre Dame -5.5

If Notre Dame learns to count to 11, this team still has plenty of playoff potential after the close loss to Ohio State. No doubt the Fighting Irish are angry about the objective embarrassment with how that game ended, and they’re going to take it out on the Blue Devils.

Nettuno: Notre Dame +5.5

Duke is a legit ACC contender, but even a great plan from Mike Elko won’t be as tough a matchup as Ohio State’s defense was. The Fighting Irish will present the toughest test Duke has faced by far, and while I expect a decent game, I doubt it ends within a touchdown.

Grimes: Notre Dame -5.5

The Irish played a very good Ohio State team down to the wire last game. I fully expect them to bounce back here and continue a strong CFP-worthy campaign.

Darney: Duke +5.5

I absolutely believe in my heart of hearts that the Blue Devils can pull this off, but I think it comes down to a field goal either way. Sneaky great QB matchup with Sam Hartman and Riley Leonard. Also, more credit should be handed out to Dave Clawson and Wake Forest for making Hartman what he is.

Northam: Duke +5.5

I’m taking Duke here for a few reasons. First, a Mike Elko-coached team beat a Sam Hartman-quarterbacked one just last year. Two, I think Duke’s defense — which made Clemson look silly and gives up just 8.8 points per game — is legit good. Three, it’s the first time ever that the Blue Devils have been part of College GameDay, as a host or opponent, and I don’t think they’re taking that lightly. Four, Riley Leonard has been awesome at playing mistake-free football this year.

Matt Bush-USA TODAY Sports

Opening Line: Texas A&M -5

Schuster: Arkansas +6.5

The Razorbacks, for bettor or worse, cannot stop playing close games. Gimmie the points.

Scalici: Texas A&M -6.5.

As big of a bummer as it is to lose Connor Wiegman for the season, I was actually really impressed with how Max Johnson played in the second half. I think the Aggies might have inadvertantly found a better fit for this offense.

D’Andrea: Texas A&M -6.5

I understand the Aggies are here to do the opposite of whatever I expect. They could have hired an angry swarm of bees at a fraction of the price of Jimbo Fisher and gotten the same result.

Martinelli: Texas A&M -6.5

K.J. Jefferson is a solid quarterback, but Arkansas’ 41st-ranked defense won’t be able to slow down Texas A&M. Probably. Maybe.

Nettuno: Arkansas +6.5.

Losing Conner Weigman is tough, but the Aggies have one of the nation’s most experienced backups in Max Johnson, who played well last week. This feels like a must-win game for both teams, and while I fear Arkansas’ defensive issues may cost it the win, I expect a close battle in Jerry World.

Grimes: Arkansas +6.5

I have no clue what to do with A&M, man. I really don’t.

Darney: Texas A&M -6.5

I have no idea. None.

Northam: Arkansas +6.5

The Razorbacks showed real fight in the last two weeks against BYU and LSU. They’ll keep this one close, and just might win it.

Photo by Eakin Howard/Getty Images

Opening Line: James Madison -1

Schuster: South Alabama +3

This could’ve been a pretty sweet spot for College GameDay to show up this week. Two elite G5 teams that I’ve gone back-and-forth on all week. Give me a Jaguars team that whooped Oklahoma State in Stillwater in Week 3 (and has played a bit tougher schedule overall).

Scalici: South Alabama +3

A potential breakthrough moment for the Jags. They’re playing confident and having fun.

D’Andrea: James Madison -3

The Dukes have the recipe to that comeback sauce.

Martinelli: James Madison -3

Undefeated Dukes all the way on vibes only.

Nettuno: James Madison -3

These are two great G5 teams, and South Alabama has an impressive 33-7 road win over Oklahoma State. But JMU also boasts a big win over Troy, and I think the Dukes pull this one out against the Sun Belt West’s other powerhouse.

Grimes: James Madison -3

The Dukes should be able to replicate Central Michigan’s win over South Alabama last week.

Darney: James Madison -3

The Dukes are good and only like really good, cool teams lose to them, especially after hour-long rain delays and holding an 11-point lead. [cries in Virginia]

Northam: James Madison -3

It’s a travesty that the NCAA is keeping the Dukes out of bowl contention again this year. James Madison is in the conversation for the best Group of Five team this season. They’ll prove that again against a tough South Alabama team.

AJ Reynolds/Athens Banner-Herald via AP

Opening Line: Georgia -16

Schuster: Georgia -14.5

Auburn looked horrendous against Texas A&M. Georgia is going to crush the Tigers….right?

Scalici: Georgia -14.5

Do not understand this spread AT ALL. This may not be the best Georgia team we’ve seen under Kirby but Auburn’s offense is an absolute disaster. Georgia might be able to cover this spread by scoring two touchdowns and a field goal.

D’Andrea: Georgia -14.5

I haven’t seen anything from the Tigers that suggests they can cover this, even at Jordan-Hare.

Martinelli: Georgia -14.5

The Tigers do not have their [expletive] together — especially on offense, good grief — and Georgia is going to crush them. Even at home, a team that barely put up 10 points against Texas A&M is going to struggle to keep up with the Bulldogs.

Nettuno: Georgia -14.5

Georgia may have taken a step back, and there will be teams that may give them a run for their money. An Auburn squad that has one of the worst offenses in the Power Five won’t be one of them.

Grimes: Georgia -14.5

Auburn couldn’t score on A&M. No way they’re covering this.

Darney: Georgia -14.5

Dawgs are going to roll.

Northam: Georgia -14.5

I’m not sure why this line moved down by a point and a half, but I don’t think it matters. This one is going to be ugly.

Joe Nicholson-USA TODAY

Opening Line: Washington -21.5

Schuster: Washington -18.5

The Huskies took a 14-6 lead before their offense even touched the ball against Cal in Week 4. Seven plays later it held a 21-6 lead. Say a prayer for Arizona.

Scalici: Washington -18.5

This Huskies offense is absolutely terrifying. I keep waiting to see it hit a ceiling and it just keeps right on going.

D’Andrea: Washington -18.5

Even when the Huskies look bad they look pretty good.

Martinelli: Washington -18.5

If you haven’t seen what Michael Penix Jr. can do, you’re not paying attention and should probably tune in. My dark-horse preseason Heisman pick, Penix is a star who leads all quarterbacks nationally with 1,636 passing yards and 16 touchdowns on the season. Huskies by a lot.

Nettuno: Washington -18.5

The Huskies have the most potent passing attack in the nation, and I don’t expect Arizona to be any match in this one.

Grimes: Washington -18.5

The Huskies gave up 32 points to Cal and still cleared the Bears by 27. I could see a similar result here.

Darney: Washington -18.5

Dawgs are going to roll, but Husky dogs this time.

Northam: Washington -18.5

Penix for Heisman?

AP Photo/Chuck Burton

Will the only 0-5 ATS team in college football finally get the job done at Missouri?

Opening Line: Mizzou -10

Schuster: Vandy will continue to honor its still-under-construction stadium by failing to play a complete game once again.

Scalici: Mizzou -13.5. The Tigers are gonna walk right through those ‘Dores.

D’Andrea: I am going to murder you, Blake.

Martinelli: Nooooope.

Nettuno: I don’t even want to be around anymore.

Grimes: I really hope they do. For the sake of us all.

Darney: Absolutely not.

Northam: The answer is still no.